Akuammine (vincamajoridine) is an indole alkaloid. It is the most abundant alkaloid found in the seeds from the tree Picralima nitida, commonly known as akuamma, comprising 0.56% of the dried powder. It has also been isolated from Vinca major. Akuamma has been used for ages by the Ghanaian people to relieve pain, as it has opiate constituents. The powder is prepared from peeled seeds and can be taken directly or used to make capsules.