From the Vendor: Adrafinil directly affects the central nervous system, but its exact mechanisms of actions have yet to be discovered. Animal research theorizes that Adrafinil works as an a1-adrenergic receptor agonist and affects amino acid release such as glutamate while decreasing the release of GABA (1).
Adrafinil is an eugregoric agent, meaning that it promotes wakefulness and alertness without amphetamine-like effects. The World Anti-Doping Agency (WADA) classifies it a “non-specified stimulant” (2).
When ingested, Adrafinil metabolizes into the active modafinil, which is then metabolized into inactive modafinilic acid, or the inactive modafinilic sulfone. Adrafinil can also metabolize into the inactive modafinilic acid which bypasses modafinil entirely (2).
1. Milgram, Norton W., et al. “Adrafinil: A Novel Vigilance Promoting Agent.” CNS Drug Reviews, vol. 5, no. 3, 1999, pp. 193–212., doi:10.1111/j.1527-3458.1999.tb00100.x.
2. “Adrafinil”. Published Aug 27, 2014. Last updated Oct 2, 2018. https://examine.com/supplements/adrafinil/.